Mike is an angry rich kid who trys to control women. Brice is an Adonis who gets all the girls and is everyone's best friend; he deals drugs and develops a cocaine addiction. Roswell is a broke lazy pothead who thinks attractive women are unattainable. Jenny is an easy-going dream girl with no past. Lauren is a nice girl who's stuck in a relationship she can't end.

Over the course of one school year, Brice, Roswell, and Mike find out that getting high all the time, having sex, and living the party life isn't that easy. College House is a black comedy that glorifies the flaws of the twenty something male.